Breakthrough egg freezing process offers new hope

For those women needing to put off pregnancy due to illness, work, not having a partner or other personal or medical reasons, but desirous of young healthy eggs to fertilize when motherhood beckons them, consider egg preservation.

In 1953 the first (fowl) sperm cryopreservation was reported. In 1986, Australian fertility specialist Dr. Christopher Chen reported the world’s first pregnancy using slow frozen oocytes (eggs) from a British controlled-rate freezer.

For many years doctors recommended a controlled-rate and slow freezing cryopreservation process to store eggs which offered less than exemplary results for women hoping to become pregnant. Prior to 2002, the success rate of live births from frozen eggs was a mere 1-3% globally.

Today however, an innovative new flash-freezing procedure known as Vitrification is on the rise showcasing stellar results at fertility clinics across the globe.

Vitrification is the latest breakthrough in egg freezing. It is a rapid freezing technique in which a high concentration of cryoprotectant (which is like a form of anti-freeze) is used in place of the water in the cell. Now free of ice and crystals, (which in the past had diminished egg survival rates) the resultant egg is now a solid glass-like cell. Eggs can successfully be stored for years. Most doctors seem to agree that this new procedure greatly improves the chances of egg survival during the freezing and subsequent thawing process.

When a woman is ready to use her stored frozen eggs an embryologist will need to inject the hardened shell with a needle carrying sperm for fertilization to occur. This technique is known as ICSI or Intracytoplasmic Sperm Injection.

A female egg is the largest cell in the human body. Containing a large amount of water, the ice crystals that form during a slow freeze can jeopardize the integrity of the cell.

The vitrification process is showing enormous improvement in egg survival rates, fertilization, pregnancies and ultimately births.

As with the formerly widely used slow-freeze cryopreservation technique, resultant chromosomal abnormalities remain consistent with those not using either of these freezing methods.

According to a report from the American Society of Reproductive Medicine’s official journal Fertility and Sterility, “the techniques of vitrification of oocytes and the subsequent warming process being used today are producing results equal to those using fresh oocytes and are, certainly, far superior to those utilizing slow-freezing techniques”.

With major advancements in our knowledge of egg/oocyte preservation, oocyte physiology and new laboratory techniques, the success of egg preservation is rapidly changing.

With egg/oocyte survival rates of over 90% after vitrification and warming, fertilization rates of 75%–90%, pregnancy rates of 32%–65%, and live-birth rates of over 50% , these numbers bring new hope to those who have had to delay pregnancy.

Should women take Prometrium to ward off miscarriage?

To sustain a healthy pregnancy, women must maintain healthy levels of progesterone at all times.

As a woman’s body prepares for ovulation, progesterone levels go up. The corpus luteum can stimulate the production of progesterone for about two weeks and if a conception occurs, the pregnancy itself takes over the stimulation of progesterone. With no pregnancy, the lining of the uterus deteriorates and a period begins.

If a newly pregnant woman’s progesterone level begins to diminish, then miscarriage would be imminent.

Many women who have experienced one or more miscarriages or are known to have a luteal phase defect (LPD) are being presented with a new option by their providers.

Prometrium, a synthetic form of progesterone that may help maintain a pregnancy and ward off miscarriage. Normally prescribed to menopausal women requiring hormone therapy and/or women experiencing abnormal periods, Prometrium can also be prescribed to women experiencing spotting or bleeding early in the first trimester or women with a history of recurrent miscarriage.

Available in tablet form a doctor will generally prescribe a 100-200mg dose to be taken orally once or twice a day. Suppositories and cream are available as well.

To determine the efficacy and safety of progestogens like Prometrium as a preventative therapy against miscarriage, a recent study (by Haas DM, Ramsey PS ‘Progestogen for preventing miscarriage’ Cochrane Database of Systematic Reviews 2008, Issue 2) was conducted on 2118 women who participated in 15 trials. The study revealed no significant difference between progestogen and placebo or no treatment groups for a majority of the participants.

However, in a subgroup analysis of three trials involving women who had recurrent miscarriages (3 or more), treatment showed a statistically significant decrease in the miscarriage rate compared to placebo or no treatment.

Additionally, no significant adverse effects from taking Prometrium were reported regarding mother and child at this time, however many people feel there are not enough facts supporting its safety and warranting its overuse.

According to their own website, the most common adverse events reported in (postmenopausal) women receiving prometrium 200 mg were: breast tenderness, dizziness, abdominal bloating, vaginal discharge, chest pain, and diarrhea.

And most importantly, they actually warn not to use while pregnant. 

Further research indicated the long-term maternal and neonatal/fetal adverse effects of progestogen administration in early pregnancy also warrant further investigation.

Until then many non-supporters feel it is imperative Progestogen be removed from the treatment list for preventing miscarriage. Increasing awareness among policy-makers, health-care providers and patients about the fact that the practice is not based on evidence is a good start.

Success rate of in vitro fertilization (IVF)

For many women, the “baby quest” can be an emotionally daunting and costly experience, devoting many years and big bucks to the cause. According to the most recent National Summary and Fertility Clinic Report from the U.S. Department of Health and Human Services Centers for Disease Control and Preventionabout 12% of women of childbearing age in the United States have used an infertility service and the percentage of women who give birth using an infertility aid each year is steadily climbing. When natural methods fail, many women between the ages of 28 and 48 are turning to an assisted reproductive technology technique called In Vitro Fertilization (IVF).

Of the 422 fertility clinics in operation and participating in this report during this time, 134,260 ART cycles were performed resulting in 38,910 births for a success rate of 29%. The majority of women using ART techniques ranged between the ages of 30-39 (68%). Women 40+ made up an additional 21%.

The IVF process begins when a woman stimulates her ovaries by taking an oral medication like Clomidor Serophene to produce or develop eggs. She can also be monitored for natural egg production via ultra-sounds or blood work. Once her egg(s) reach maturation and are potentially viable they are removed during an outpatient medical procedure called follicular aspiration which entails sending a thin needle through the vaginal canal and into each ovary (follicle) containing the egg(s). With the needle connected to a suction apparatus, it removes the egg(s) and fluid from each ovary. Mild cramping may occur for a short period of time.

In lab, the egg(s) and sperm are combined to create an embryo or embryos. Under a watchful eye, technicians monitor the development of the embryo(s) and days later, the most viable one(s) are selected and transferred through the vaginal canal, cervix, and then into the uterus during an outpatient procedure at a doctor’s office, fertility clinic or hospital. If the procedure is successful, a woman will know if she is pregnant within two weeks.

The IVF method has been used successfully in the United States since 1981. Studies support a higher percentage of conception success rates with embryo transfers to the uterus occurring on day 3 and day 5 out of the 1 to 6 day window of opportunity for this procedure.

Many factors come into play in the success of IVF such as age, origin of infertility, ovarian reserve, FSH level, semen attributes, the woman’s response to treatment, general over-all health condition, the use of a woman’s own fresh egg(s), frozen egg(s) or donor egg(s), emotional state, health insurance coverage and monetary concerns.

There are a number of other ART techniques to consider in addition to IVF such as GIFT and ZIFT with the latter being a minimally invasive surgical procedure performed laparoscopically (MIS) with a small incision (2-3cm) made through the abdomen. A woman will gain a better understanding of which procedure(s) she is a better candidate for after consulting with her OB/GYN or fertility specialist.

Although multiple embryo transfers may pose more of a health risk concern for both the mother and babies, studies suggest the rate of successful live births does increase with more than one embryo transfer.

As a woman matures, her viable egg(s) begin to diminish, especially after 40. For these women, there is another option. A donor egg. Studies reflect that even women over 40 may have a 52% success rate using a donor egg. Women who have trouble carrying to term but whose egg(s) are viable may want to consider a surrogate or gestational carrier. The same IVF method would apply to the surrogate.

Additionally, women who have previously been pregnant and/or given birth through natural methods or using ART techniques are known to have a higher chance of conceiving and birthing once again using ART methods.

Couples who are experiencing low sperm count may choose to use Intracytoplasmic Sperm Injection (ICSI) where a single sperm is injected directly into a woman’s egg for a better likelihood of fertilization. This process is used in conjunction with IVF.

The Society for Assisted Reproductive Technology (SART), an organization of ART providers affiliated with the American Society for Reproductive Medicine (ASRM), has been collecting data and publishing annual reports of pregnancy success rates for fertility clinics in the United States and Canada since 1989.

General information on clinics in your area and throughout the U.S. who are members of The Society for Assisted Reproductive Technology (SART) can be obtained by calling 205.978.5000, extension 109.

According to the Advanced Fertility Center of Chicago, the average cost of a single IVF cycle is approximately $9500, not including medications.

If you live in and have health insurance coverage in one of the following 13 states, you may receive partial to full coverage for infertility issues, IVF cycles or ART procedures. Check with your insurance provider as states mandate different infertility coverage such as lifetime infertility treatment benefit caps of $15,000, 1 IVF session or no IVF cycle – but include other treatments like fertility medications or artificial insemination.

Currently, the list includes Arkansas, California, Connecticut, Texas, Hawaii, Illinois, Maryland, Massachusetts, Montana, New York, Ohio, Rhode Island and West Virginia while Florida and other states are currently under consideration for state mandates concerning these types of procedures.

Pregnancy after 40

My only child is approaching his 21st Birthday, I’ve been happily married for eight great years and I decide at the ripe age of forty-three; that’s right a 4 and a 3 to embark on the ultimate journey of baby-making once again!

My husband’s AARP application arrived in the mail recently along with his firefighter retirement check – he just turned 50. He barely looks 40. I tell him it’s genetics, he jokes it’s from not having to raise a few kids.

I know how psyched my 20-year-old son is about having a sibling. He has no idea how psyched I am about having a free 20-year-old babysitter!

After years of mulling it over, hours of discussion, passionately over-analyzing the subject with no definitive resolution, questions arise; the brain goes on overload.

Do I really want to start the whole process again? Will we still be able to travel and work?

And what about raising the kid? Public or private school? Minivan or SUV?

Or as my husband says, Lions or Bears fan? Red Wings or Black Hawks? And how much is college going to be in the year 2026? Will we be cashing in the house for two semesters of college?

And who’s the designated babysitter when the free twenty-year-old gets tired of smelly diapers?

Our cat sitter is only $17 a day and that includes two feedings and one litter box clean-up; wonder if she’ll be available! Some other friends recently turned their loving dog-sitter Paula into their Nanny for their two babies.

Grandma Nancy’s out of service. She’s in Michigan helping with 17 grandkids at the over-ripe age of 82.

What if the little one is allergic to the cats? Who goes, the kid or the cats? What if we have multiples? Won’t even go there!

Here’s a horror story. Last time I had a baby my shoe size went up ½ size. If it happens again; so much for my Donald Pliner Snake-skin sandals.

Then there’s the boob issue; will they sag after nursing and droop like half-filled water balloons. I can always get a boob-job after breast-feeding and finance the kid’s college.

What about baby-proofing the house and sleep . . . ah sleep . . . I really enjoy my sleep . . . do I really want to give up the peace and quiet I’ve come to know and love for so many years since my twenty-year-old son last woke me to his final bout of middle of the night tears so many moons ago.

“Yes.” Absolutely. Bring in the troops. I have like 48 eggs left (okay, truth is, research indicates women over 35 have 25,000-90,000 eggs)… so let’s get the show on the road, remember, I’m 43 and counting! Send in the troops at least every other day. Let’s bravely forge ahead, (divide properly) and conquer!